Clarity announced positive results from an early feasibility study evaluating VR-based 40 Hz gamma sensory stimulation in patients with Mild Cognitive Impairments (MCI) and early-stage Alzheimer’s disease (AD).

The data, presented at the Alzheimer’s Association International Conference (AAIC) on July 30th, 2025, demonstrate that delivering synchronized light and sound stimulation via Virtual Reality (VR) technology is safe, well-tolerated, and associated with acute memory improvements in this patient population.

Key outcomes (n = 11):

• Evidence that gamma light and sound stimulation through VR can evoke brain activity at gamma frequencies in early-stage AD patients and cognitively healthy participants.

• VR-based gamma sensory stimulation showed no significant adverse events and was was well-tolerated.

• VR-based gamma sensory stimulation acutely improved short- and long-term memory performance compared to sham.

“These findings extend our healthy elder results to a patient population that urgently needs a treatment.” said Raphael Certain, Clarity’s Co-Founder & CEO. “It is a foundational step toward our upcoming multi-month efficacy trial.”

These results complement the positive results previously obtained from 16 cognitively healthy elderly individuals, which were published in Scientific Reports on 5 August. For more details, refer to this article.

Complementary results from this dataset will be presented by Cofounder and Chief Scientific Officer, Carolina Reis Ph.D at the International Conference on Cognitive Neuroscience (ICON 2025), 15–20 September 2025 in Oporto, Portugal.